Clinical Research into Male Fertility

When a couple is trying to conceive, the reproductive health of both partners is an important factor. A man’s sperm quality can be affected by the overproduction of reactive oxygen species; combating ROS is one of the clinically studied effects that can support male fertility ǂ

Proxeed® plus a prenatal male fertility supplement, has been the subject of extensive clinical research.6, 9, 14-16 Research has demonstrated a strong positive correlation between several measures of sperm quality and overall sperm health; it has long been thought that an improvement in any of the factors of sperm quality will increase sperm health. 24

Proxeed plus contains an antioxidant complex and provides key nutrients needed for developing sperm such as: 5,14-17

  • Zinc, folic acid, vitamin B12, Acetyl-L-carnitine can help  maintain sperm health and motility ǂ5,12,13           
  • L-carnitine, Acetyl-L-carnitine, fructose and citric acid help optimize  energy/metabolism 5-7,10,14-20 ǂ
  • Selenium, CoQ10, vitamin C, zinc and Acetyl-L-carnitine support motility and rapid linear progression 8,11,12,22-23ǂ

Research has demonstrated a strong positive correlation between several measures of sperm quality and overall sperm health; it has long been thought that an improvement in any of the factors of sperm quality will increase sperm health. 24
Try Proxeed® plus yourself – contribute to your reproductive health with a complete carnitine based formula that targets multiple sperm functions ǂ

Support Motility with Proxeed® plus

Sperm motility is a term that describes the sperm’s ability to move in an active fashion: in other words, are the sperm “strong swimmers”? In healthy sperm, typically more than 50% are active, with over 25% moving forcefully in one direction. Motility is what enables sperm to travel up the cervical canal, via the uterus to the fallopian tubes and penetrate the egg. It is estimated that in a healthy male, more than 25% of his sperm will exhibit rapid linear progression (forward or straight movement), these sperm have the best chance of success.
 
Numerous studies, including several double-blind placebo-controlled trials, have shown that the ingredients in Proxeed® plus maintain sperm motility in menǂ. The ingredients’ ability to maintain motility is probably from energy production, specifically by transporting long chain fatty acids into the mitochondria and providing readily available acetyl groups for utilization in the Krebs cycle.25 The metabolic activity that results contributes to optimized energy production and motility.

Oxidative Stress and Sperm Health

Reactive Oxygen Species (ROS)
Humans need oxygen for their cellular function. As the human cells use oxygen in their usual functions they produce metabolites. These metabolites, also known as reactive oxygen species (ROS), can be lethal to the same cells that created themǂ. ROS is a class of metabolites that are unstable and chemically reactive. One or more of their electrons are unpaired, and this causes them to be highly reactive.

What does ROS have to do with you?
High levels of ROS can change male fertility. High concentrations of ROS can have an effect on sperm metabolism and motilityǂ27.

High Levels of Oxidative Stress
Studies have shown that high levels of oxidative stress may affect:

Main Types of ROS in Seminal Plasma
High concentrations of any or all of these may lower male fertility17, 26

  • Hydrogen peroxide (main ROS produced in sperm).
  • Superoxide anion
  • Hydroxyl radical

Oxidative Stress Overproduction
ROS Overproduction
ROS overproduction results in seminal oxidative stress and is associated with sperm function such as: 17,26

    • Sperm concentration
    • Sperm motility, and
    • Sperm morphology

The antioxidant properties of L-carnitine, acetyl-L-carnitine, Vitamin C, CoQ10, selenium and Vitamin B12 can help sperm healthǂ5-8,11,21,22 The antioxidant benefit of Proxeed® plus supports sperm health when reactive oxygen species (ROS) overproduction is likely to occur, thereby maintaining male fertilityǂ.

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This site is intended for use by U.S. healthcare professionals only.

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This site is intended for use by U.S. healthcare professionals only.

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