Proxeed Plus Carnitine-based Formula

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Proxeed® plus is a complete carnitine-based formula for male fertility that targets multiple sperm functions. Playing a key role in supporting normal sperm developmentǂ and included in Proxeed® plus are L-Carnitine (LC) (fumarate) and Acetyl-L-carnitine (ALC). 
  • Carnitines are among the most clinically supported ingredient compared to all other nutrients in the field of male fertilityǂ.
    • Some patients have lower levels of L-carnitine (LC) and Acetyl-L-Carnitine (ALC) in seminal plasma. In men, a balanced LC: ALC ratio can help:
      • Maintain seminal plasma levelsǂ
      • Maintain sperm healthǂ
      • Maintain sperm quality, an essential factor in a couple’s fertilityǂ
    • Acetyl-L-Carnitine serves as a circulating energy source for sperm and provides primary fuel for sperm motility 5-8
    • LC/ALC supports the following functions
      • sperm motility morphology, concentration and count 17-20
      • supports normal sperm development in the presence of free radicals 9,14-16, 27ǂ
      • sperm factors affected: count concentration and motilityǂ

Each packet of Proxeed® plus contains 1.7 grams of L-Carnitine fumarate (1.0g of L-Carnitine) and 0.5g of Acetyl-L-carnitine.

Proxeed® plus is a complete carnitine-based formula for male fertility that targets multiple sperm functionsǂ.
  • Selenium is a powerful antioxidantǂ
  • Selenium aids in the integrity of the sperm flagella to support motility and rapid linear progression11ǂ

  Each packet of Proxeed® plus delivers 50 mcg of Selenium, 71% of the daily recommended value.

Proxeed® plus is a prenatal male supplement combining a unique blend of ingredients to support male fertility and sperm healthǂ.
  • Zinc, blended into Proxeed® plus is important for
    • Semen production and contributes to fertility and reproduction12ǂ.

1 packet of Proxeed® plus delivers 10 mg, 67% of the daily value, of zinc.

Proxeed® plus is a complete carnitine-based formula including antioxidant and energy-promoting agent Coenzyme Q10, to support male fertility and sperm healthǂ.
  • Coenzyme Q10 is an antioxidant
    • Antioxidants are important support for free radical balance in male fertilityǂ.
  • Coenzyme Q10 is also a metabolic substrate and is concentrated in the mitochondria of the mid-piece of the sperm
    • Supporting cellular energy; maintains integrity of sperm flagellaǂ21,22
  • Sperm factors affected: Motilityǂ17,21,22.

Proxeed® plus contains 20 mg of Coenzyme Q10 in each packet.

Proxeed® plus is a complete carnitine based formula combining a unique blend of ingredients, to support sperm health such as Vitamin C, an antioxidant present in the seminal plasmaǂ.
  • Vitamin C is a key antioxidant that supports sperm metabolic processes:
    • Antioxidants in seminal plasma supports motility23ǂ
    • Sperm factors affected
      • Countǂ
      • Concentrationǂ
      • Motilityǂ

Each packet of Proxeed® plus contains 90 mg of Vitamin C (as L-Ascorbic Acid) to deliver 150% of the daily value

Proxeed® plus is a complete carnitine based formula for male fertility that targets multiple sperm functionsǂ.
  • Folic acid, most commonly found in leafy greens, is essential during cell maturation and contributes to the quality of seminal fluid 13,8ǂ.
  • Studies suggest that supplementation of folic acid, along with zinc, improves sperm healthǂ

Each packet of Proxeed® plus contains 200 mcg of folic acid (50% of the daily value).

Proxeed® plus supports normal sperm development, male fertility and reproductionǂ.
  • Vitamin B12 is involved in cell maturation and DNA synthesis.
  • Deficiencies in B12 have been associated with decreased sperm count and motilityǂ.

1 packet of Proxeed® plus contains 1.5 mcg of this essential nutrient providing 25% of the daily value.

Supplement Facts

Serving Size 1 Packet

 Amount Per Serving% Daily Value
Calories10 
Total Carbohydrate2 g<1%ǂǂ
Sugars1 g
Vitamin C (as L-Ascorbic acid)90 mg150%
Zinc (as Zinc lactate trihydrate) Folic Acid Selenium (as Selenium yeast) Vitamin B12 (as Cyanocobalamin 0.1%)10 mg 200 mcg 50 mcg 1.5 mcg67% 50% 71% 25%
L-carnitine fumarate (providing 1.0g L-carnitine)1.7 g
Acetyl-L-carnitine HCI0.5 g
Citric Acid50 mg
Coenzyme Q1020 mg
ǂǂPercent daily values are based on a 2,000 calorie diet. ✝Percent daily values not established.

Other Ingredients: Sugar, Fructose, Lemon flavor, Acesulfame K, Silicon Dioxide.

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References

  1. Carlsen E. et al., BMJ 305 (1992): 609-13.
  2. Cooper TG et al., Human Reproduction Update. 2010; 16.3: 231-245
  3. Sharlip ID et al., Fertil. Steril. 2002; 77.5: 873-882
  4. Agarwal A & Sekhon LH., Human Fertility. 2010; 13(4): 217-225
  5. Agarwal A, Said TM. Reprod Biomed Online. 2004; 8(4):376-84. www.rbmonline.com/Article/1200 on web 3 February 2004.
  6. Agarwal A, et al. Reprod Biomed Online. 2004; 8(6):616-627. www.rbmonline.com/Article/1284 on web 7 April 2004.
  7. Vicari E, Calogero AE. Human Reproduction. 2001; 16(11):2338-2342.
  8. Vicari E, La Vignera S, Calogero AE. Fertil. Steril. 2002; 78(6):1203-1208.
  9. Costa M, Canale D, Filicori M et al. Andrologia. 1994 May-Jun; 26(3):155-159.
  10. Golan R, Shalev DP, Wasserzug O et al. J Reprod Fertil. 1986; 78(1):287-293.
  11. Scott R, et al. Br J Urol 1998; 82:76-80.
  12. Wong WY, Thomas CM, Merkus JM et al. Fertil Steril. 2000 Mar; 73(3):435-442. Review.
  13. Wong WY, Merkus HM, Thomas CM et al. Fertil Steril. 2002; 77(3):491-498.
  14. Cavallini G, Ferraretti AP, Gianaroli L et al. J Androl. 2004 Sep-Oct;25(5):761-770.
  15. Lenzi A, Sgro P, Salacone P et al. Fertil. Steril. 2004 Jun;81(6):1578-1584.
  16. Garolla A, Maiorino M, Roverato A et al. Fertil. Steril. 2005 Feb; 83(2):355-361.

  1. Saleh RA, Agarwal A, Nada EA et al. Fertil. Steril. 2003 Jun; 79 Suppl 3:1597-1605.
  2. Data on file. Proxeed® plus product information Sigma-Tau Pharmaceuticals, Inc.
  3. Hendin BN, Kolettis PN, Sharma RK et al. J Urol. 1999 Jun;161(6):1831-1834.
  4. Kolettis PN, Sharma RK, Pasqualotto FF et al. Fertil. Steril. 1999 Feb;71(2):249-255.
  5. Balercia G, Mosca F, Mantero F et al. Fertil. Steril. 2004 Feb; 81(1):93-98.
  6. Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med. 1997 (18 Suppl.):S213-S219.
  7. Dawson EB et al. Fertil. Steril. 1992 Nov;58(5):1034-1039.
  8. http://www.uptodate.com/contents/evaluation-of-male-infertility/abstract/14?utdPopup=true
  9. Rivlin J, Mendel J, Rubinstein S et al. Role of hydrogen peroxide in sperm capacitation and acrosome reaction. Biol. Reprod. 2004 Feb; 70(2):518-22. Epub 2003 Oct 15.
  10. Sharma RK, Agarwal A. Urology. 1996 Dec; 48(6):835-850. Review.
  11. Padron OF, Brackett NL, Sharma RK et al. Fertil. Steril. 1997 Jun; 67(6):1115-1120.
  12. Pasqualotto FF, Sharma RK, Potts JM et al. Urology. 2000 June; 55(6):881-885.
  13. de Lamirande E, Jiang H, Zini A., et al. Reactive oxygen species and sperm physiology. Hum. Reprod. 2000; 15(6): 1314-1321.
  14. Aziz N, Saleh RA, Sharma RK et al. Fertil. Steril. 2004 Feb; 81(2):349-354.

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